MelanA Recombinant Rabbit Monoclonal Antibody [SC56-02] (ET1610-47)
Catalog# ET1610-47
Rabbit Monoclonal to MelanA
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WB
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IHC-P
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Human
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Mouse
Positive control:
Lane 1: Melanoma tissue lysate
Lane 2: B16F1 cell lysate
Specifications
Product Type
Recombinant Rabbit monoclonal primary
Product Name
MelanA Recombinant Rabbit Monoclonal Antibody [SC56-02] (ET1610-47)
Immunogen
Synthetic peptide within human melana aa 2-43 / 118.
Host
Rabbit
Positive Control
Melanoma tissue lysate, B16F1 cell lysate, human melanoma tissue.
Conjugation
Unconjugated
Clonality
Monoclonal
Clone Number
SC56-02
RRID
APPLICATION DILUTION
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WB
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1:500-1:2,000
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IHC-P
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1:200
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Protein A affinity purified.
Molecular Weight
Predicted band size: 13 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
MelanA
SYNONYMS
Antigen LB39 AA antibody;Antigen LB39-AA antibody;Antigen SK29 AA antibody;Antigen SK29-AA antibody;MAR1_HUMAN antibody;MART 1 antibody;MART-1 antibody;MART1 antibody;Melan A antibody;Melan A protein antibody;Melanoma antigen recognized by T cells 1 antibody;Melanoma antigen recognized by T-cells 1 antibody;MLAN A antibody;MLANA antibody;OTTHUMP00000021036 antibody;OTTHUMP00000021037 antibody;OTTHUMP00000021038 antibody;Protein Melan-A antibody
TISSUE SPECIFICITY
Expression is restricted to melanoma and melanocyte cell lines and retina.
POST-TRANSLATIONAL MODIFICATION
Acylated.
SUBCELLULAR LOCATION
Golgi apparatus, trans-Golgi network membrane, Endoplasmic reticulum membrane, Melanosome.
FUNCTION
Melanoma-associated antigens recognized by cytotoxic T lymphocytes (CTL) have been grouped into three categories: melanocyte differentiation antigens, cancer/testis-specific antigens and mutated or aberrantly expressed antigens. Many of these antigens consist of peptides that are presented to T cells by HLA molecules; they represent potential targets for cancer immunotherapy. Melan-A (also designated MART-1) is a melanocyte differentiation antigen that is specific to melanomas, melanocyte cell lines and retina. Melan-A peptide is recognized by most HLA-A2-restricted tumor-specific tumor-infiltrating lymphocytes in patients with melanoma. Antimelanoma cytotoxic T lymphocytes can be generated with a Melan-A peptide, implicating Melan-A as a potential candidate for antigen-specific immunotherapy in melanoma patients.
CITATIONS
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Yu Jinhai,et al
Three-Dimensional Cell Spheroid Culture and Proliferation Activity Study of Uveal Melanoma Cell Line C918
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IHC
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Human
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Citation
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Zhang, Y., Zeng, H., Hu, Y., Jiang, L., Fu, C., Zhang, L., Zhang, F., Zhang, X., Zhu, L., Huang, J., Chen, J., & Zeng, Q.
Establishment and validation of evaluation models for post-inflammatory pigmentation abnormalities
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Human
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Citation
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