MEF2A + MEF2C Recombinant Rabbit Monoclonal Antibody [JE63-26] (HA721030)

UNIPROT #

Q02078

PROTEIN NAME

MEF2A + MEF2C

SYNONYMS

ADCAD1 antibody;MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A) antibody;MEF2 antibody;MEF2A antibody;MEF2A_HUMAN antibody;Myocyte enhancer factor 2A antibody;Myocyte-specific enhancer factor 2A antibody;RSRFC4 antibody;RSRFC9 antibody;Serum response factor like protein 1 antibody;Serum response factor-like protein 1 antibody;C5DELq14.3 antibody;DEL5q14.3 antibody;MADS box transcription enhancer factor 2 polypeptide C (myocyte enhancer factor 2C) antibody;MADS box transcription enhancer factor 2, polypeptide C antibody;MEF2C antibody;MEF2C_HUMAN antibody;Myocyte enhancer factor 2C antibody;Myocyte specific enhancer factor 2C antibody;Myocyte-specific enhancer factor 2C antibody;OTTHUMP00000222409 antibody;Similar to MADS box transcription enhancer factor 2 polypeptide C antibody

SUBCELLULAR LOCATION

Nucleus. Nucleus, sarcoplasm.

FUNCTION

The protein encoded by MEF2A is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene. This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe cognitive disability, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described.