MED12 Recombinant Rabbit Monoclonal Antibody [PSH06-67] (HA722739)

UNIPROT #

Q93074

PROTEIN NAME

MED12

SYNONYMS

Activator recruited cofactor 240 kDa component antibody;Activator-recruited cofactor 240 kDa component antibody;ARC240 antibody;CAG repeat protein 45 antibody;CAGH45 antibody;HOPA antibody;KIAA0192 antibody;MED12 antibody;MED12_HUMAN antibody;Mediator complex subunit 12 antibody;Mediator of RNA polymerase II transcription subunit 12 antibody;OPA containing protein antibody;OPA-containing protein antibody;Thyroid hormone receptor associated protein complex 230 kDa component antibody;Thyroid hormone receptor-associated protein complex 230 kDa component antibody;TNRC11 antibody;Trap230 antibody;Trinucleotide repeat containing gene 11 protein antibody;Trinucleotide repeat-containing gene 11 protein antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Mediator of RNA polymerase II transcription, subunit 12 homolog (S. cerevisiae), also known as MED12, is a human gene found on the X chromosome. Mutations in MED12 are responsible for at least two different forms of X-linked dominant mental retardation, Lujan-Fryns syndrome and FG syndrome, as well as instances of prostate cancer. Mutations in MED12 are associated with uterine leiomyomas and breast fibroepithelial tumors (e.g. fibroadenoma and phyllodes tumors).