Applications
-
WB
-
IHC
-
FC
REACTIVITY
-
Human
-
Mouse
SPECIFICATIONS
Product Type
Rabbit polyclonal primary
Product Name
Meckelin Rabbit Polyclonal Antibody (0903-7)
Immunogen
Synthetic peptide within human meckelin aa 20-80.
Host
Rabbit
Positive Control
MCF-7 cell lysates, mouse kidney tissue, human placenta tissue, human breast cancer tissue, PANC-1.
Conjugation
Unconjugated
Clonality
Polyclonal
PROPERTIES
Form
Liquid
Storage Condition
Store at +4Á¾ after thawing. Aliquot store at -20Á¾. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Peptide affinity purified.
MOLECULAR WEIGHT
112 kDa
Isotype
IgG
APPLICATION DILUTION
-
WB
-
1:500-1:1,000
-
IHC
-
1:50-1:200
-
FC
-
1:50-1:100
TARGET
UNIPROT #
PROTEIN NAME
Meckelin
SYNONYMS
JBTS6 antibody; Meckel syndrome type 3 protein antibody; MKS3 antibody; NPHP11 antibody; TMEM67 antibody; TNEM67 antibody; Transmembrane protein 67 antibody
SUBCELLULAR LOCATION
Cytoskeleton, Plasma membrane, Endoplasmic reticulum.
FUNCTION
Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in centrosome migration to the apical cell surface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC).