MDA5 Recombinant Rabbit Monoclonal Antibody [PSH03-56] (HA722015)

UNIPROT #

Q9BYX4

PROTEIN NAME

MDA5

SYNONYMS

CADM-140 autoantigen antibody;Clinically amyopathic dermatomyositis autoantigen 140 kDa antibody;DEAD/H (Asp Glu Ala Asp/His) box polypeptide antibody;DEAD/H box polypeptide antibody;Helicard antibody;Helicase with 2 CARD domains antibody;Hlcd antibody;IDDM 19 antibody;IDDM19 antibody;IFIH 1 antibody;Ifih1 antibody;IFIH1_HUMAN antibody;Interferon induced helicase C domain containing protein 1 antibody;interferon induced with helicase C domain 1 antibody;Interferon induced with helicase C domain protein 1 antibody;Interferon-induced helicase C domain-containing protein 1 antibody;Interferon-induced with helicase C domain protein 1 antibody;MDA 5 antibody;MDA-5 antibody;Melanoma differentiation associated protein 5 antibody;Melanoma differentiation-associated gene 5 antibody;Melanoma differentiation-associated protein 5 antibody;MGC133047 antibody;Murabutide down regulated protein antibody;Murabutide down-regulated protein antibody;RH 116 antibody;RH116 antibody;RIG I like receptor 2 antibody;RLR 2 antibody;RNA helicase DEAD box protein 116 antibody;RNA helicase-DEAD box protein 116 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Mitochondrion.

FUNCTION

MDA5 (melanoma differentiation-associated protein 5) is a RIG-I-like receptor dsRNA helicase enzyme that is encoded by the IFIH1 gene in humans. MDA5 is part of the RIG-I-like receptor (RLR) family, which also includes RIG-I and LGP2, and functions as a pattern recognition receptor capable of detecting viruses. It is generally believed that MDA5 recognizes double stranded RNA (dsRNA) over 2000nts in length, however it has been shown that whilst MDA5 can detect and bind to cytoplasmic dsRNA, it is also activated by a high molecular weight RNA complex composed of ssRNA and dsRNA. For many viruses, effective MDA5-mediated antiviral responses are dependent on functionally active LGP2. The signaling cascades in MDA5 is initiated via CARD domain. Some observations made in cancer cells show that MDA5 also interacts with cellular RNA is able to induce an autoinflammatory response.