MCRS1 Rabbit Polyclonal Antibody (HA500120)

UNIPROT #

Q96EZ8

PROTEIN NAME

MCRS1

SYNONYMS

58 kDa microspherule protein antibody;Cell cycle regulated factor (78 kDa) antibody;Cell cycle regulated factor p78 antibody;Cell cycle-regulated factor p78 antibody;ICP22BP antibody;INO80 complex subunit J antibody;MCRS 1 antibody;MCRS 2 antibody;MCRS1 antibody;MCRS1_HUMAN antibody;MCRS2 antibody;Microspherule protein 1 antibody;MSP 58 antibody;MSP58 antibody;p78 antibody

SUBCELLULAR LOCATION

Nucleus, Nucleolus, Cytoplasm.

FUNCTION

MSP58, also known as MCRS1 (microspherule protein 1), P78 or INO80Q, is a 462 amino acid protein that localizes to the nucleus and contains one FHA domain. Expressed at high levels during the S phase of the cell cycle and present in testis, prostate, thymus, spleen and colon, MSP58 functions to modulate the transcriptional activity of Daxx (a transcriptional repressor) by recruiting Daxx to the nucleolus. Additionally, MSP58 may play a role in the inhibition of TERT telomerase activity, further implicating MSP58 as an important protein in transcriptional regulation. The gene encoding MSP58 maps to human chromosome 12 and is expressed as multiple alternatively spliced isoforms. Encoding over 1,100 genes within 132 million bases, chromosome 12 makes up about 4.5% of the human genome and is associated wirh hypochondrogenesis, achondrogenesis and Kniest dysplasia.