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MCM7 Rabbit Polyclonal Antibody (ER1902-60)

Price: Regular price $315.00

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Catalog# ER1902-60

Rabbit Polyclonal to MCM7

Tested for

  • WB

  • IHC-P

  • IF-Cell

  • FC

React with

  • Human

  • Mouse

  • Rat

Specifications

Product Type

Rabbit polyclonal primary

Product Name

MCM7 Rabbit Polyclonal Antibody (ER1902-60)

Immunogen

Recombinant protein corresponding to c terminal human mcm7.

Host

Rabbit

Positive Control

MCF-7 cell lysate, K562 cell lysate, mouse colon tissue lysate, MCF-7, MG-63, SHSY5Y, human lung cancer tissue, human colon tissue, mouse skin tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

APPLICATION DILUTION

  • WB

  • 1:500-1:2,000

  • IHC-P

  • 1:50-1:200

  • IF-Cell

  • 1:50-1:200

  • FC

  • 1:50-1:100

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

Predicted band size 81/60/45 kDa

Isotype

IgG

TARGET

UNIPROT #

P33993

PROTEIN NAME

MCM7

SYNONYMS

CDABP0042 antibody;CDC 47 antibody;CDC47 antibody;CDC47 homolog antibody;Cdc47, S. cerevisiae, homolog of antibody;DNA replication licensing factor MCM7 antibody;Homolog of S. cerevisiae Cdc47 antibody;MCM 2 antibody;MCM 7 antibody;MCM2 antibody;MCM2, formerly antibody;Mcm7 antibody;MCM7 minichromosome maintenance deficient 7 antibody;MCM7_HUMAN antibody;Minichromosome Maintainence 7 antibody;Minichromosome maintainence, S. cerevisiae, homolog of antibody;Minichromosome maintenance complex component 7 antibody;Minichromosome maintenance deficient 7 antibody;Minichromosome maintenance protein 7 antibody;P1.1 MCM3 antibody;P1.1-MCM3 antibody;P1CDC47 antibody;P85MCM antibody;PNAS 146 antibody;PNAS146 antibody;PPP1R104 antibody;Protein phosphatase 1, regulatory subunit 104 antibody

SEQUENCE SIMILARITIES

Belongs to the MCM family.

POST-TRANSLATIONAL MODIFICATION

O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage. Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex.

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