MCM7 Mouse Monoclonal Antibody [15E1] (EM1901-12)

UNIPROT #

P33993

PROTEIN NAME

MCM7

SYNONYMS

CDABP0042 antibody;CDC 47 antibody;CDC47 antibody;CDC47 homolog antibody;Cdc47, S. cerevisiae, homolog of antibody;DNA replication licensing factor MCM7 antibody;Homolog of S. cerevisiae Cdc47 antibody;MCM 2 antibody;MCM 7 antibody;MCM2 antibody;MCM2, formerly antibody;Mcm7 antibody;MCM7 minichromosome maintenance deficient 7 antibody;MCM7_HUMAN antibody;Minichromosome Maintainence 7 antibody;Minichromosome maintainence, S. cerevisiae, homolog of antibody;Minichromosome maintenance complex component 7 antibody;Minichromosome maintenance deficient 7 antibody;Minichromosome maintenance protein 7 antibody;P1.1 MCM3 antibody;P1.1-MCM3 antibody;P1CDC47 antibody;P85MCM antibody;PNAS 146 antibody;PNAS146 antibody;PPP1R104 antibody;Protein phosphatase 1, regulatory subunit 104 antibody

SEQUENCE SIMILARITIES

Belongs to the MCM family.

POST-TRANSLATIONAL MODIFICATION

O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage. Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex.