MCL1 Rabbit Polyclonal Antibody (R1510-26)

UNIPROT #

Q07820

PROTEIN NAME

MCL1

SYNONYMS

Bcl 2 related protein EAT/mcl1 antibody;Bcl-2-like protein 3 antibody;Bcl-2-related protein EAT/mcl1 antibody;BCL2 related antibody;Bcl2-L-3 antibody;BCL2L3 antibody;EAT antibody;Induced myeloid leukemia cell differentiation protein Mcl 1 antibody;Induced myeloid leukemia cell differentiation protein Mcl-1 antibody;MCL 1 antibody;MCL1 antibody;MCL1-ES antibody;mcl1/EAT antibody;MCL1_HUMAN antibody;MCL1L antibody;MCL1S antibody;MGC104264 antibody;MGC1839 antibody;Myeloid Cell Leukemia 1 antibody;Myeloid cell leukemia ES antibody;Myeloid cell leukemia sequence 1 antibody;Myeloid cell leukemia sequence 1 BCL2 related antibody;Myeloid cell leukemia sequence 1 isoform 1 antibody;OTTHUMP00000032794 antibody;OTTHUMP00000032795 antibody;TM antibody

SEQUENCE SIMILARITIES

Belongs to the Bcl-2 family.

POST-TRANSLATIONAL MODIFICATION

Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment.; Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region.; Phosphorylated on Ser-159, by GSK3, in response to IL3/interleukin-3 withdrawal. Phosphorylation at Ser-159 induces ubiquitination and proteasomal degradation, abrogating the anti-apoptotic activity. Treatment with taxol or okadaic acid induces phosphorylation on additional sites.; Ubiquitinated. Ubiquitination is induced by phosphorylation at Ser-159.

SUBCELLULAR LOCATION

Membrane. Cytoplasm. Mitochondrion.

FUNCTION

B-cell CLL/lymphoma 2 (Bcl-2) blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal. Myeloid cell leukemia 1 (Mcl-1) shares sequence homology with Bcl-2 and further resembles Bcl-2 in that its expression promotes cell viability. p53 and Mcl-1 demonstrate opposing effects on mitochondrial apoptosis by mediating Bcl-2 antagonist killer (Bak) activity. Mcl-1 is an important and specific regulator that is necessary for the homeostasis of early hematopoietic progenitors. Glycogen synthase kinase 3 (GSK3) controls Mcl-1 stability, which has an effect on the regulation of apoptosis by growth factors, PI 3-kinase and AKT. Mice with a deficiency of the Mcl-1 protein show a significant reduction in B and T lymphocytes similar to the effects observed in IL-7- or IL-7R-deficient mice.