MC1-R Recombinant Rabbit Monoclonal Antibody [JE39-49] (HA721377)

UNIPROT #

Q01726

PROTEIN NAME

MC1-R

SYNONYMS

CMM5 antibody;MC1 Receptor antibody;MC1-R antibody;MC1R antibody;Melanocortin 1 receptor antibody;Melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) antibody;Melanocortin receptor 1 antibody;Melanocyte-stimulating hormone receptor antibody;Melanotropin receptor antibody;MSH-R antibody;MSHR antibody;MSHR_HUMAN antibody;SHEP2 antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.