Recombinant Rabbit monoclonal primary
MBD2 Recombinant Rabbit Monoclonal Antibody [JE57-73] (ET7111-40)
Synthetic peptide within n-terminal human mbd2.
Raji cell lysates, rat kidney tissue, human lung carcinoma tissue, human breast carcinoma tissue, Daudi.
Store at +4Á¾ after thawing. Aliquot store at -20Á¾. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
Demethylase antibody; DMTase antibody; MBD 2 antibody; Mbd2 antibody; MBD2_HUMAN antibody; MBD2a antibody; Methyl CpG binding domain protein 2 antibody; Methyl CpG binding protein MBD2 antibody; Methyl-CpG-binding domain protein 2 antibody; Methyl-CpG-binding protein MBD2 antibody; NY CO 41 antibody
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.