MBD1 Recombinant Rabbit Monoclonal Antibody [PSH01-78] (HA721730)

UNIPROT #

Q9UIS9

PROTEIN NAME

MBD1

SYNONYMS

CXXC 3 antibody;CXXC-type zinc finger protein 3 antibody;CXXC3 antibody;MBD 1 antibody;Mbd1 antibody;MBD1_HUMAN antibody;MECP1 COMPLEX antibody;Methyl CpG binding domain protein 1 antibody;Methyl CpG binding domain protein 1 isoform PCM1 antibody;Methyl CpG binding protein MBD1 antibody;Methyl CpG binding protein splice variant 1 antibody;Methyl CpG binding protein splice variant 2 antibody;Methyl CpG binding protein splice variant 3 antibody;Methyl CpG binding protein splice variant 4 antibody;Methyl-CpG-binding domain protein 1 antibody;Methyl-CpG-binding protein MBD1 antibody;PCM 1 antibody;PCM1 antibody;Protein containing methyl-CpG-binding domain 1 antibody;Regulator of fibroblast growth factor 2 (FGF 2) transcription antibody;RFT antibody;The regulator of fibroblast growth factor 2(FGF 2) transcription antibody

SUBCELLULAR LOCATION

Nucleus, Nucleus matrix, Nucleus speckle, Chromosome

FUNCTION

MBD1 is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.