MAT2A Rabbit Polyclonal Antibody (HA500028)

UNIPROT #

P31153

PROTEIN NAME

MAT2A

SYNONYMS

AdoMet synthase 2 antibody;AdoMet synthetase 2 antibody;AdoMet synthetase antibody;AMS 2 antibody;AMS2 antibody;MAT 2 antibody;MAT 2A antibody;MAT II antibody;MAT-II antibody;Mat2a antibody;MATA 2 antibody;MATA2 antibody;MATII antibody;Methionine adenosyltransferase 2 antibody;Methionine adenosyltransferase antibody;Methionine adenosyltransferase II alpha antibody;Methionine adenosyltransferase II antibody;METK2_HUMAN antibody;S adenosylmethionine synthetase gamma form antibody;S adenosylmethionine synthetase isoform type 2 antibody;S-adenosylmethionine synthase isoform type-2 antibody;SAMS 2 antibody;SAMS2 antibody

SUBCELLULAR LOCATION

Nucleoplasm, Cytosol.

FUNCTION

Protein expression is regulated by post-transcriptional regulation: in presence of S-adenosyl-L-methionine, METTL16 binds and methylates the first hairpin of the 3'-UTR region of MAT2A mRNA, impairing MAT2A expression . In S-adenosyl-L-methionine-limiting conditions, METTL16 binds the 3'-UTR region of MAT2A mRNA without methylating it due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A . Consequences of N6-methylation of MAT2A are however subject to discussion: According to a report, N6-methylation of MAT2A affects MAT2A mRNA splicing ). According to a second report, N6-methylation of MAT2A affects MAT2A mRNA stability (By similarity).By similarity1 Publication.