Rabbit polyclonal primary
MAT2A Rabbit Polyclonal Antibody (HA500028)
Recombinant protein within human mat2a aa 70-260.
Rat kidney tissue lysates, rat kidney tissue, human colon tissue, human colon carcinoma tissue, mouse brain tissue.
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein affinity purified.
AdoMet synthase 2 antibody; AdoMet synthetase 2 antibody; AdoMet synthetase antibody; AMS 2 antibody; AMS2 antibody; MAT 2 antibody; MAT 2A antibody; MAT II antibody; MAT-II antibody; Mat2a antibody; MATA 2 antibody; MATA2 antibody; MATII antibody; Methionine adenosyltransferase 2 antibody; Methionine adenosyltransferase antibody; Methionine adenosyltransferase II alpha antibody; Methionine adenosyltransferase II antibody; METK2_HUMAN antibody; S adenosylmethionine synthetase gamma form antibody; S adenosylmethionine synthetase isoform type 2 antibody; S-adenosylmethionine synthase isoform type-2 antibody; SAMS 2 antibody; SAMS2 antibody
Protein expression is regulated by post-transcriptional regulation: in presence of S-adenosyl-L-methionine, METTL16 binds and methylates the first hairpin of the 3'-UTR region of MAT2A mRNA, impairing MAT2A expression . In S-adenosyl-L-methionine-limiting conditions, METTL16 binds the 3'-UTR region of MAT2A mRNA without methylating it due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A . Consequences of N6-methylation of MAT2A are however subject to discussion: According to a report, N6-methylation of MAT2A affects MAT2A mRNA splicing ). According to a second report, N6-methylation of MAT2A affects MAT2A mRNA stability (By similarity).By similarity1 Publication.