Mouse monoclonal primary
MASP2 Mouse Monoclonal Antibody [F3-4] (M1501-11)
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Mannan binding lectin serine peptidase 2 antibody; Mannan binding lectin serine protease 2 antibody; Mannose binding protein associated serine protease 2 antibody; MAP 19 antibody; MAP19 antibody; MASP 2 antibody; MBL associated plasma protein of 19 kD antibody; MBL associated serine protease 2 antibody; Small MBL associated protein antibody; sMAP antibody
Belongs to the ku70 family.
Expression does not increase during promyelocyte differentiation.
Phosphorylation by PRKDC may enhance helicase activity. Phosphorylation of Ser-51 does not affect DNA repair.; ADP-ribosylated by PARP3.
Mannan-binding lectin serine protease 2 also known as mannose-binding protein-associated serine protease 2 (MASP-2) is an enzyme that in humans is encoded by the MASP2 gene. MASP-2 involved in the complement system. MASP-2 is very similar to the C1s molecule, of the classical complement pathway, and they are thought to have a common evolutionary ancestor. When the carbohydrate-recognising heads of MBL bind to specifically arranged mannose residues on the surface of a pathogen, MASP-2 is activated to cleave complement components C4 and C2 into C4a, C4b, C2a, and C2b.