PRODUCT CODE: M1501-11

MASP2 Mouse Monoclonal Antibody [F3-4] (M1501-11)

Applications

  • WB

REACTIVITY

  • Human

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+
Western blot analysis on human serum lysates using anti-MASP2 mouse mAb.
  • Western blot analysis on human serum lysates using anti-MASP2 mouse mAb.
Western blot analysis on human serum lysates using anti-MASP2 mouse mAb.

Applications

  • WB

REACTIVITY

  • Human

SPECIFICATIONS

Product Type

Mouse monoclonal primary

Product Name

MASP2 Mouse Monoclonal Antibody [F3-4] (M1501-11)

Immunogen

Peptide

Host

Mouse

Positive Control

Human serum

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

F3-4

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

2 ug/ul

PURIFICATION

Protein A purified.

MOLECULAR WEIGHT

~76kDa

Isotype

IgG2b

APPLICATION DILUTION

  • WB

  • 1:2,000-1:5,000

TARGET

UNIPROT #

PROTEIN NAME

MASP2

SYNONYMS

Mannan binding lectin serine peptidase 2 antibody; Mannan binding lectin serine protease 2 antibody; Mannose binding protein associated serine protease 2 antibody; MAP 19 antibody; MAP19 antibody; MASP 2 antibody; MBL associated plasma protein of 19 kD antibody; MBL associated serine protease 2 antibody; Small MBL associated protein antibody; sMAP antibody

SEQUENCE SIMILARITIES

Belongs to the ku70 family.

DEVELOPMENTAL STAGE

Expression does not increase during promyelocyte differentiation.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation by PRKDC may enhance helicase activity. Phosphorylation of Ser-51 does not affect DNA repair.; ADP-ribosylated by PARP3.

SUBCELLULAR LOCATION

Secreted

FUNCTION

Mannan-binding lectin serine protease 2 also known as mannose-binding protein-associated serine protease 2 (MASP-2) is an enzyme that in humans is encoded by the MASP2 gene. MASP-2 involved in the complement system. MASP-2 is very similar to the C1s molecule, of the classical complement pathway, and they are thought to have a common evolutionary ancestor. When the carbohydrate-recognising heads of MBL bind to specifically arranged mannose residues on the surface of a pathogen, MASP-2 is activated to cleave complement components C4 and C2 into C4a, C4b, C2a, and C2b.