MAPKAP Kinase 2 Recombinant Rabbit Monoclonal Antibody [JU30-31] (ET7106-83)

UNIPROT #

P49137

PROTEIN NAME

MAPKAP Kinase 2

SYNONYMS

MAP kinase activated protein Kinase 2 antibody;MAP kinase-activated protein kinase 2 antibody;MAPK activated protein kinase 2 antibody;MAPK-activated protein kinase 2 antibody;MAPK2_HUMAN antibody;MAPKAP K2 antibody;MAPKAP kinase 2 antibody;MAPKAPK 2 antibody;MAPKAPK-2 antibody;MAPKAPK2 antibody;Mitogen activated protein kinase activated protein kinase 2 antibody;MK 2 antibody;MK2 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

TISSUE SPECIFICITY

Expressed in all tissues examined.

POST-TRANSLATIONAL MODIFICATION

Sumoylation inhibits the protein kinase activity.; Phosphorylated and activated by MAP kinase p38-alpha/MAPK14 at Thr-222, Ser-272 and Thr-334.

SUBCELLULAR LOCATION

Cytoplasm. Nucleus.

FUNCTION

The MAPKAP kinases (for MAP kinase activated protein kinases) are a group of MAP kinase substrates which are themselves kinases. In response to activation, the MAP kinases phosphorylate downstream components on a consensus Pro-X-Ser/Thr-Pro motif. Several kinases that contain this motif have been identifed and serve as substrates for the ERK and p38 MAP kinases. These include the serine/threonine kinases Rsk-1 (also designated MAPKAP kinase-1), Rsk-2 and Rsk-3, which are phosphorylated by ERK1 and ERK2. Similarly, p38 phosphorylates and activates the serine/threonine kinases MAPKAP kinase-2 and MAPKAP kinase-3 (also designated 3pK). The serine/threonine kinases Mnk1 and Mnk2 are substrates for both ERK and p38 MAP kinases.