Mannose Receptor(CD206) Recombinant Antibody [PSH07-76] - Guinea pig IgG2 (Chimeric) (HA601452)

UNIPROT #

Q61830

PROTEIN NAME

Mannose Receptor(CD206)

SYNONYMS

bA541I19.1 antibody;C type lectin domain family 13 member D antibody;C-type lectin domain family 13 member D antibody;CD 206 antibody;CD206 antibody;CD206 antigen antibody;CLEC13D antibody;CLEC13DL antibody;Macrophage mannose receptor 1 antibody;Macrophage mannose receptor 1 like protein 1 antibody;Macrophage mannose receptor antibody;Mannose receptor C type 1 antibody;Mannose receptor C type 1 like 1 antibody;MMR antibody;MRC 1 antibody;MRC1 antibody;MRC1_HUMAN antibody;MRC1L1 antibody;OTTHUMP00000045206 antibody

SUBCELLULAR LOCATION

Endosome membrane, Cell membrane.

FUNCTION

The mannose receptor (Cluster of Differentiation 206, CD206) is a C-type lectin primarily present on the surface of macrophages, immature dendritic cells and liver sinusoidal endothelial cells, but is also expressed on the surface of skin cells such as human dermal fibroblasts and keratinocytes. It is the first member of a family of endocytic receptors that includes Endo180 (CD280), M-type PLA2R, and DEC-205 (CD205). The receptor recognises terminal mannose, N-acetylglucosamine and fucose residues on glycans attached to proteins found on the surface of some microorganisms, playing a role in both the innate and adaptive immune systems. Additional functions include clearance of glycoproteins from circulation, including sulphated glycoprotein hormones and glycoproteins released in response to pathological events. The mannose receptor recycles continuously between the plasma membrane and endosomal compartments in a clathrin-dependent manner.