MAL Rabbit Polyclonal Antibody (R1311-6)

UNIPROT #

P21145

PROTEIN NAME

MAL

SYNONYMS

Mal antibody;MAL protein gene antibody;Mal T-cell differentiation protein antibody;MAL_HUMAN antibody;MALGENE antibody;MPV17 antibody;Myelin and lymphocyte protein antibody;T-cell differentiation protein MAL antibody;T-lymphocyte maturation-associated protein antibody;VIP17 antibody

SEQUENCE SIMILARITIES

Belongs to the MAL family.

DEVELOPMENTAL STAGE

Expressed in the intermediate and late stages of T-cell differentiation.

POST-TRANSLATIONAL MODIFICATION

Lipoprotein.

SUBCELLULAR LOCATION

Membrane

FUNCTION

Myelin and lymphocyte protein is a protein that in humans is encoded by the MAL gene.The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3.