MAG Recombinant Antibody [PSH02-41] - Guinea pig IgG2 (Chimeric) (HA601510)

UNIPROT #

P20917

PROTEIN NAME

MAG

SYNONYMS

GMA antibody;MAG antibody;MAG_HUMAN antibody;Myelin associated glycoprotein antibody;Myelin-associated glycoprotein antibody;S MAG antibody;S-MAG antibody;Sialic acid binding Ig like lectin 4A antibody;Sialic acid binding immunoglobulin like lectin 4A antibody;Siglec 4a antibody;Siglec-4a antibody;SIGLEC4A antibody;SPG75 antibody

SUBCELLULAR LOCATION

Cell membrane, Membrane raft.

FUNCTION

Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth (By similarity). Inhibits axon outgrowth by binding to RTN4R (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b (By similarity).