Applications
-
WB
REACTIVITY
-
Human
-
Rat
SPECIFICATIONS
Product Type
Rabbit polyclonal primary
Product Name
LT-alpha Rabbit Polyclonal Antibody (0807-5)
Immunogen
Synthetic peptide within human lt-alpha aa 55-104 / 205.
Host
Rabbit
Positive Control
Recombinant LT-alpha(TNF-β)
Conjugation
Unconjugated
Clonality
Polyclonal
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 25% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Immunogen affinity purified
MOLECULAR WEIGHT
18 kDa
Isotype
IgG
APPLICATION DILUTION
-
WB
-
1:1,000
TARGET
UNIPROT #
PROTEIN NAME
LT-alpha
SYNONYMS
LTalpha antibody; DIF antibody; LT alpha antibody; LT antibody; LT-alpha antibody; Lta antibody; Lymphotoxin alpha (TNF superfamily, member 1) antibody; Lymphotoxin alpha antibody; Lymphotoxin-alpha antibody; TNF B antibody; TNF superfamily member 1 antibody; TNF, lymphocyte-derived antibody; TNF-beta antibody; TNFB antibody; TNFB_HUMAN antibody; TNFbeta antibody; TNFSF1 antibody; TNLG1E antibody; Tumor necrosis factor beta antibody; tumor necrosis factor ligand 1E antibody; Tumor necrosis factor ligand superfamily member 1 antibody
SEQUENCE SIMILARITIES
Belongs to the tumor necrosis factor family.
SUBCELLULAR LOCATION
secretory protein
FUNCTION
Lymphotoxin-alpha (LTA), a member of the tumor necrosis factor (TNF) family of cytokines, was initially isolated on the basis of an anti-tumor activity. LTA plays a key role in communication between lymphocytes and stromal cells, thereby eliciting cytotoxic effects on cancer cells. It induces the expression of vascular cell-adhesion molecule 1 (VCAM1) on vascular endothelial cells and recruits natural killer (NK) cells to parenchymal organs and tumor lesions.