LT-alpha Rabbit Polyclonal Antibody (0807-5)

UNIPROT #

P01374

PROTEIN NAME

LT-alpha

SYNONYMS

LTalpha antibody;DIF antibody;LT alpha antibody;LT antibody;LT-alpha antibody;Lta antibody;Lymphotoxin alpha (TNF superfamily, member 1) antibody;Lymphotoxin alpha antibody;Lymphotoxin-alpha antibody;TNF B antibody;TNF superfamily member 1 antibody;TNF, lymphocyte-derived antibody;TNF-beta antibody;TNFB antibody;TNFB_HUMAN antibody;TNFbeta antibody;TNFSF1 antibody;TNLG1E antibody;Tumor necrosis factor beta antibody;tumor necrosis factor ligand 1E antibody;Tumor necrosis factor ligand superfamily member 1 antibody

SEQUENCE SIMILARITIES

Belongs to the tumor necrosis factor family.

SUBCELLULAR LOCATION

secretory protein

FUNCTION

Lymphotoxin-alpha (LTA), a member of the tumor necrosis factor (TNF) family of cytokines, was initially isolated on the basis of an anti-tumor activity. LTA plays a key role in communication between lymphocytes and stromal cells, thereby eliciting cytotoxic effects on cancer cells. It induces the expression of vascular cell-adhesion molecule 1 (VCAM1) on vascular endothelial cells and recruits natural killer (NK) cells to parenchymal organs and tumor lesions.