Western blot analysis on LT-alpha (TNF-β) using anti- LT-alpha polyclonal antibody

Applications

REACTIVITY

Human
Rat

SPECIFICATIONS

Product Type

Rabbit polyclonal primary

Product Name

LT-alpha Rabbit Polyclonal Antibody (0807-5)

Immunogen

Synthetic peptide within human lt-alpha aa 55-104 / 205.

Host

Rabbit

Positive Control

Recombinant LT-alpha(TNF-β)

Conjugation

Unconjugated

Clonality

Polyclonal

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 25% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Immunogen affinity purified

MOLECULAR WEIGHT

18 kDa

Isotype

IgG

APPLICATION DILUTION

WB
1:1,000

TARGET

UNIPROT #

P01374

PROTEIN NAME

LT-alpha

SYNONYMS

LTalpha antibody; DIF antibody; LT alpha antibody; LT antibody; LT-alpha antibody; Lta antibody; Lymphotoxin alpha (TNF superfamily, member 1) antibody; Lymphotoxin alpha antibody; Lymphotoxin-alpha antibody; TNF B antibody; TNF superfamily member 1 antibody; TNF, lymphocyte-derived antibody; TNF-beta antibody; TNFB antibody; TNFB_HUMAN antibody; TNFbeta antibody; TNFSF1 antibody; TNLG1E antibody; Tumor necrosis factor beta antibody; tumor necrosis factor ligand 1E antibody; Tumor necrosis factor ligand superfamily member 1 antibody

SEQUENCE SIMILARITIES

Belongs to the tumor necrosis factor family.

SUBCELLULAR LOCATION

secretory protein

FUNCTION

Lymphotoxin-alpha (LTA), a member of the tumor necrosis factor (TNF) family of cytokines, was initially isolated on the basis of an anti-tumor activity. LTA plays a key role in communication between lymphocytes and stromal cells, thereby eliciting cytotoxic effects on cancer cells. It induces the expression of vascular cell-adhesion molecule 1 (VCAM1) on vascular endothelial cells and recruits natural killer (NK) cells to parenchymal organs and tumor lesions.