Positive control:
Lane 1: HepG2 cell lysate
Lane 2: K562 cell lysate
Lane 3: Human liver tissue lysate
Applications
-
WB
-
IHC-P
REACTIVITY
-
Human
-
Mouse
SPECIFICATIONS
Product Type
Rabbit polyclonal primary
Product Name
LSS Rabbit Polyclonal Antibody (HA500011)
Immunogen
Recombinant protein within human lss aa 1-200.
Host
Rabbit
Positive Control
HepG2 cell lysate, K562 cell lysate, human liver tissue lysate, human colon carcinoma tissue, human skin tissue, human placenta tissue, mouse liver tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
PROPERTIES
Form
Liquid
Storage Condition
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Protein affinity purified.
MOLECULAR WEIGHT
Predicted band size: 74 kDa.
Isotype
IgG
APPLICATION DILUTION
-
WB
-
1:500-1:1,000
-
IHC-P
-
1:100-1:500
TARGET
UNIPROT #
PROTEIN NAME
LSS
SYNONYMS
2,3 epoxysqualene lanosterol cyclase antibody; LSS; hOSC antibody; Lanosterol synthase (2,3 oxidosqualene lanosterol cyclase) antibody; Lanosterol synthase antibody; OSC antibody; Oxidosqualene lanosterol cyclase antibody
SUBCELLULAR LOCATION
Endoplasmic reticulum membrane.
FUNCTION
The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.