LSP1 Recombinant Rabbit Monoclonal Antibody [SN06-25] (ET1611-9)

UNIPROT #

P33241

PROTEIN NAME

LSP1

SYNONYMS

47 kDa actin binding protein antibody;47 kDa actin-binding protein antibody;52 kDa phosphoprotein antibody;F actin binding and cytoskeleton associated protein antibody;Leufactin (leukocyte F-actin binding protein) antibody;Leufactin antibody;Leukocyte F actin binding protein antibody;Leukocyte specific protein 1 antibody;LSP 1 antibody;Lsp1 antibody;LSP1_HUMAN antibody;Lymphocyte specific antigen WP34 antibody;Lymphocyte specific protein 1 antibody;Lymphocyte specific protein pp52 antibody;Lymphocyte-specific antigen WP34 antibody;Lymphocyte-specific protein 1 antibody;OTTHUMP00000014138 antibody;OTTHUMP00000014139 antibody;OTTHUMP00000014140 antibody;OTTHUMP00000069612 antibody;OTTHUMP00000069614 antibody;OTTHUMP00000069615 antibody;OTTHUMP00000069616 antibody;pp52 antibody;Protein pp52 antibody;S37 protein antibody;WP 34 antibody;WP34 antibody

TISSUE SPECIFICITY

Activated T-lymphocytes.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by casein kinase II, protein kinase C and MAPKAPK2. Phosphorylation by PKC induces translocation from membrane to cytoplasm. Phosphorylation by MAPKAPK2 may regulate neutrophil chemotaxis (By similarity).

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

pp52 (human) or LSP1 (murine) is a hematopoietic-expressed gene that encodes an F-actin-binding, leukocyte-specific (including B and T lymphocytes, granulocytes and macrophages), phosphoprotein. However, mRNA splice variants that do not encode the lympho-specific protein are expressed from this gene in nonlymphoid cell lines as well (myocytes, stromal cells and fibroblasts), suggesting pp52 has a divergent role in signal transduction. The pp52 (LSP1) locus maps to human chromosome 11p15.5, which is implicated in tumor-related chromosomal translocations found in chronic lymphocytic leukemia. The pp52 promoter contains key elements that control transcriptional activity including an initiator specifying the unique 5' terminus of pp52 mRNA, tandem pairs of Ets and SP1 motifs, and a single C/EBP motif. LSP1 binds the cytoskeleton and has been implicated in affecting cytoskeletal remodeling in a variety of leukocyte functions, including cell motility and chemotaxis.