LSD1 Rabbit Polyclonal Antibody (ER1802-12)

UNIPROT #

O60341

PROTEIN NAME

LSD1

SYNONYMS

Amine oxidase (flavin containing) domain 2 antibody;Amine oxidase, flavin containing, 2 antibody;AOF2 antibody;BHC110 antibody;BRAF35 HDAC complex protein BHC110 antibody;BRAF35-HDAC complex protein BHC110 antibody;BRAF35/HDAC complex, 110-kD subunit antibody;CPRF antibody;EC1 antibody;FAD binding protein BRAF35 HDAC complex, 110 kDa subunit antibody;Flavin-containing amine oxidase domain-containing protein 2 antibody;KDM 1 antibody;KDM1 antibody;Kdm1a antibody;KDM1A_HUMAN antibody;KIAA0601 antibody;LSD 1 antibody;LSD1 antibody;Lysine (K) specific demethylase 1 antibody;Lysine (K) specific demethylase 1A antibody;Lysine demethylase 1A antibody;Lysine specific histone demethylase 1 antibody;Lysine specific histone demethylase 1A antibody;Lysine-specific demethylase 1 antibody;Lysine-specific demethylase 1A antibody;Lysine-specific histone demethylase 1A antibody

SEQUENCE SIMILARITIES

Belongs to the flavin monoamine oxidase family.

TISSUE SPECIFICITY

Ubiquitously expressed.

POST-TRANSLATIONAL MODIFICATION

Polyubiquitinated by JADE2; which leads to its proteasomal degradation.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Histone methylation regulates chromatin structure and transcription and maintains an epigenetic state of the cell. Histone methylation is dynamically regulated by histone methylases and demethylases. Lysine-specific histone demethylase 1 (LSD1), also designated BHC110, is a flavin-dependent amine oxidase which catalyzes the removal of one or two methyl groups from the methyl-lysine-4 side chain of Histone H3. The LSD1 protein contains a SWIRM domain, a FAD-binding motif and an amine oxidase domain. Association with CoREST, a SANT domain-containing corepressor, positively regulates LSD1. CoREST mediates the demethylation ability of LSD1 and protects it from proteasomal degradation in vivo. PHF21A (also designated BCH80), a PHD domain-containing protein, inhibits activity of LSD1/CoREST mediated de-methylation. The LSD1 protein also co-localizes with the androgen receptor in human prostate tumor cells and in unaffected prostate cells, stimulating androgen-receptor-dependent transcription.