PRODUCT CODE: M1211-4

LRP-1 Mouse Monoclonal Antibody [A4-F5] (M1211-4)

Applications

  • WB

  • IHC-P

REACTIVITY

  • Mouse

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Western blot analysis on recombinant protein using anti-LRP-1 Mouse mAb (Cat. # M1211-4).
  • Western blot analysis on recombinant protein using anti-LRP-1 Mouse mAb (Cat. # M1211-4).
  • Immunohistochemical analysis of paraffin- embedded mouse liver tissue using anti-LRP-1 Mouse mAb (Cat. # M1211-4).
Western blot analysis on recombinant protein using anti-LRP-1 Mouse mAb (Cat. # M1211-4).

Applications

  • WB

  • IHC-P

REACTIVITY

  • Mouse

SPECIFICATIONS

Product Type

Mouse monoclonal primary

Product Name

LRP-1 Mouse Monoclonal Antibody [A4-F5] (M1211-4)

Immunogen

Recombinant protein

Host

Mouse

Positive Control

Recombinant protein

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

A4-F5

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

2 ug/ul

PURIFICATION

Protein A purified.

MOLECULAR WEIGHT

48 kDa

Isotype

IgG2a

APPLICATION DILUTION

  • WB

  • 1:1,000

  • IHC-P

  • 1:50

TARGET

UNIPROT #

PROTEIN NAME

LRP-1

SYNONYMS

A2MR antibody; Alpha 2 macroglobulin receptor antibody; alpha 2MR antibody; Alpha-2-macroglobulin receptor antibody; APOER antibody; Apolipoprotein E receptor antibody; APR antibody; CD 91 antibody; CD91 antibody; CD91 antigen antibody; IGFBP3R antibody; LDL receptor related protein 1 antibody; Low density lipoprotein receptor related protein 1 antibody; Low density lipoprotein related protein 1 antibody; Low-density lipoprotein receptor-related protein 1 intracellular domain antibody; LRP 1 antibody; LRP 515 antibody; LRP 85 antibody; LRP antibody; LRP ICD antibody; LRP-1 antibody; LRP-515 antibody; LRP-85 antibody; Lrp1 antibody; LRP1 protein antibody; LRP1_HUMAN antibody; LRP1A antibody; LRP515 antibody; LRP85 antibody; LRPICD antibody; MGC88725 antibody; Prolow density lipoprotein receptor related protein 1 antibody; TbetaR V/LRP 1/IGFBP 3 receptor antibody; TbetaRV/LRP1/IGFBP3 receptor antibody; TGFBR 5 antibody; TGFBR5 antibody; Type V tgf beta receptor antibody

SEQUENCE SIMILARITIES

Belongs to the LDLR family.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated on serine and threonine residues.; Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1 (By similarity).; Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane (By similarity).

SUBCELLULAR LOCATION

cell membrane

FUNCTION

The LDL receptor-related protein (LRP1) is a large endocytic receptor that is widely expressed in several tissues. LRP1 is a member of the LDL receptor family that plays diverse roles in various biological processes including lipoprotein metabolism, degradation of proteases, activation of lysosomal enzymes, and cellular entry of bacterial toxins and viruses.