LPP Recombinant Rabbit Monoclonal Antibody [JE55-29] (ET7111-02)

UNIPROT #

Q93052

PROTEIN NAME

LPP

SYNONYMS

DKFZp779O0231 antibody;FLJ30652 antibody;FLJ41512 antibody;LIM domain containing preferred translocation partner in lipoma antibody;LIM domain-containing preferred translocation partner in lipoma antibody;LIM protein antibody;Lipoma preferred partner antibody;Lipoma-preferred partner antibody;lpp antibody;LPP_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the zyxin/ajuba family.

TISSUE SPECIFICITY

Expressed in a wide variety of tissues but no or very low expression in brain and peripheral leukocytes.

SUBCELLULAR LOCATION

Nucleus, cell membrane, cytoplasm, cell junction.

FUNCTION

This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants.