UNIPROT #

P61794

PROTEIN NAME

LPA receptor 1

SYNONYMS

5031439C20 antibody; AI326300 antibody; EDG 2 antibody; Endothelial differentiation gene 2 antibody; Endothelial differentiation, lysophosphatidic acid G protein coupled receptor, 2 antibody; GPCR 26 antibody; Gpcr26 antibody; Gpcr91 antibody; GPR26 antibody; Kdt2 antibody; LPA 1 antibody; LPA receptor 1 antibody; LPA receptor EDG2 antibody; LPA-1 antibody; lpA1 antibody; Lpar1 antibody; LPAR1_HUMAN antibody; Lysophosphatidic acid receptor 1 antibody; Lysophosphatidic acid receptor Edg-2 antibody; Lysophosphatidic acid receptor EDG2 antibody; MGC105279 antibody; MGC29102 antibody; Mrec1.3 antibody; rec.1.3 antibody; Ventricular zone gene 1 antibody; vzg-1 antibody; VZG1 antibody

SEQUENCE SIMILARITIES

Belongs to the G-protein coupled receptor 1 family.

TISSUE SPECIFICITY

Detected in brain corpus callosum, medulla oblongata, cerebellum and sciatic nerve. Detected in heart.

POST-TRANSLATIONAL MODIFICATION

N-glycosylated.

SUBCELLULAR LOCATION

Cell membrane

FUNCTION

Lysophosphatidic acid receptor 1 also known as LPAR1 is a gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule lysophosphatidic acid (LPA). The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Alternative splicing of this gene has been observed and two transcript variants have been described, each encoding identical proteins.