LOX Recombinant Rabbit Monoclonal Antibody [JU30-23] (ET1706-31)

UNIPROT #

P28300

PROTEIN NAME

LOX

SYNONYMS

lox antibody;LYOX antibody;LYOX_HUMAN antibody;Lysyl oxidase antibody;MGC105112 antibody;Protein lysine 6 oxidase antibody;Protein-lysine 6-oxidase antibody

SEQUENCE SIMILARITIES

Belongs to the lysyl oxidase family.

TISSUE SPECIFICITY

Heart, placenta, skeletal muscle, kidney, lung and pancreas.

POST-TRANSLATIONAL MODIFICATION

The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.; Proteolytically cleaved by BMP1 which removes the propeptide. Also proteolytically cleaved by ADAMTS2 and ADAMTS14, but not by ADAMTS3, at an additional cleavage site downstream of the BMP1 cleavage site. The propeptide plays a role in directing the deposition of this enzyme to elastic fibers, via interaction with tropoelastin (By similarity). Cleavage by BMP1 to remove the propeptide does not increase enzymatic activity but increases binding to collagen. Cleavage by ADAMTS2 produces a form with reduced collagen-binding activity.; Sulfated at Tyr-187 and also at either Tyr-183 or Tyr-184 which enhances binding to collagen.

SUBCELLULAR LOCATION

Secreted, extracellular space.

FUNCTION

The lysyl oxidase family of extracellular proteins includes LOX and four LOX-like enzymes, which are responsible for the deamination of peptidyl lysine residues of collagens and elastin. They also catalyze inter- and intra-crosslinking reactions. Overexpression of LOX may cause severe fibrotic degeneration due to its high resistance to degradative enzymes. Procollagen C-proteinase activity processes LOX from a precursor protein to a mature form. Activation of LOX occurs in normal developing and adult skin, and alterations in LOX expression and activity are associated with skin aging and senescence. LOX is crucial for development of the cardiovascular and respiratory systems. In addition, LOX plays a role in cancer, wound healing, as well as cell motility, chemotaxis and differentiation.