UNIPROT #

P78380

PROTEIN NAME

LOX-1

SYNONYMS

C-type lectin domain family 8 member A antibody; CLEC8A antibody; hLOX 1 antibody; hLOX-1 antibody; Lectin like oxidized LDL receptor 1 antibody; Lectin like oxLDL receptor 1 antibody; Lectin type oxidized LDL receptor 1 antibody; Lectin-like oxidized LDL receptor 1 antibody; Lectin-like oxLDL receptor 1 antibody; Lectin-type oxidized LDL receptor 1 antibody; low density lipoprotein oxidized, receptor 1 antibody; LOX-1 antibody; LOXIN antibody; Olr1 antibody; OLR1_HUMAN antibody; Ox LDL receptor 1 antibody; Ox-LDL receptor 1 antibody; Oxidised low density lipoprotein (lectin like) receptor 1 antibody; Oxidized low density lipoprotein receptor 1 antibody; Oxidized low density lipoprotein receptor 1 soluble form antibody; Oxidized low-density lipoprotein receptor 1 antibody; SCARE1 antibody; Scavenger receptor class E, member 1 antibody; SLOX1 antibody; soluble form antibody; SR-EI antibody

TISSUE SPECIFICITY

Expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra. Also expressed at the surface of dendritic cells. Widely expressed at intermediate and low level.

POST-TRANSLATIONAL MODIFICATION

The intrachain disulfide-bonds prevent N-glycosylation at some sites.; N-glycosylated.

SUBCELLULAR LOCATION

Cell membrane. Secreted.

FUNCTION

The oxidized low density lipoprotein (lectin-like) receptor-1, Ox-LDL R-1, is a type II membrane protein that is a member of the C-type lectin family and acts as a cell-surface receptor for oxidized low density lipoprotein (Ox-LDL). Ox-LDL plays a role in early atherosclerosis, which includes the transformation of monocyte-derived macrophages to foam cells in atherosclerotic lesions. The binding of Ox-LDL to Ox-LDL R-1 may also trigger the activation of the NFkB signal transduction pathway. Ox-LDL R-1, also designated scavenger receptor class E, member 1 (SCARE1); lectin-type oxidized LDL receptor 1 (LOX-1); and CLEC8A), is expressed by vascular endothelial cells, smooth muscle cells and macrophages. It is expressed endogenously as a precursor form with N-linked high mannose carbohydrate chains and as a mature form due to further glycosylation. The N-linked glycosylation of Ox-LDL R-1 appears to be necessary for adequate transportation to the cell surface and efficient ligand binding.