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Loricrin Recombinant Rabbit Monoclonal Antibody (IRS165RB)

Price: Regular price $278.00

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Catalog# IRS165RB

Rabbit Monoclonal to Loricrin

Tested for

  • mIHC

Reacts with

  • Mouse

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Loricrin Recombinant Rabbit Monoclonal Antibody (IRS165RB)

Immunogen

Synthetic peptide within human loricrin aa 1-100.

Host

Rabbit

Positive Control

Mouse skin tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

APPLICATION DILUTION

  • mIHC

  • 1:100

PROPERTIES

Form

Liquid

Storage Condition

Shipped at 4C. Store at +4C short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20C long term.

Storage Buffer

1*PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclean 950.

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 26 kDa

Isotype

IgG

TARGET

UNIPROT #

P18165

PROTEIN NAME

Loricrin

SYNONYMS

LOR antibody;LOR protein antibody;LORI_HUMAN antibody;Loricrin antibody;LRN antibody;MGC111513 antibody;OTTHUMP00000015823 antibody

SUBCELLULAR LOCATION

Cytoplasm. Nucleus.

FUNCTION

Defects in LOR are a cause of progressive symmetric erythrokeratodermia (PSEK) [MIM:133200]. Erythrokeratodermas are a group of disorders characterized by widespread erythematous plaques, either stationary or migratory, associated with features that include palmoplantar keratoderma. PSEK is characterized by erythematous and hyperkeratotic plaques. Defects in LOR are the cause of Vohwinkel syndrome with ichthyosis (VSI) [MIM:604117]; also known as loricrin keratoderma (LK) or mutilating keratoderma with ichthyosis. VSI is an ichthyotic variant of Vohwinkel syndrome (VS) characterized by progressive symmetric erythrokeratoderma or congenital ichthyosiform erythroderma born as a collodion baby. Common clinical features include hyperkeratosis of the palms and soles with digital constriction.

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