UNIPROT #

Q7TQ95

PROTEIN NAME

Lnpk

SYNONYMS

IDDM20 antibody; Lymphocyte adapter protein antibody; Lymphocyte specific adapter protein antibody; Lymphocyte specific adapter protein Lnk antibody; Lymphocyte-specific adapter protein Lnk antibody; SH2B adapter protein 3 antibody; SH2B adaptor protein 3 antibody; Sh2b3 antibody; SH2B3_HUMAN antibody; Signal transduction protein Lnk antibody

SEQUENCE SIMILARITIES

Belongs to the lunapark family.

TISSUE SPECIFICITY

Expressed in most tissues at basal level, with reinforcement in distal limb buds, genital bud, and in parts of the central nervous system.

DEVELOPMENTAL STAGE

Strongly expressed in both limb and genital buds as is the case for Evx2 and Hoxd genes, in particular Hoxd13. In developing limb buds, it is first seen in 10.5 days old fetuses, in the posterior distal bud, to subsequently extend throughout the distal aspect, in presumptive digits.

POST-TRANSLATIONAL MODIFICATION

Myristoylated; myristoylation is necessary for the endoplasmic reticulum (ER) three-way ER tubular junction formation, but is not required neither for membrane translocation, membrane topology formation, nor for the specific localization to ER membranes.; Phosphorylated. Phosphorylation occurs at Ser-177, Ser-182, Ser-222, Ser-316 and Ser-380 during interphase. Phosphorylation occurs at Ser-114, Ser-153, Ser-194, Thr-211 and Ser-348 during mitosis; these phosphorylations reduce both its homodimerization and the ER three-way tubular junction formation.; Subject to proteasomal degradation following phosphorylation during mitosis.

SUBCELLULAR LOCATION

Endoplasmic reticulum.

FUNCTION

Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology. Involved in the stabilization of nascent three-way ER tubular junctions within the ER network. May also play a role as a curvature-stabilizing protein within three-way ER tubular junction network. May be involved in limb and central nervous system development.