Lamin B2 Rabbit Polyclonal Antibody (R1408-4)

UNIPROT #

Q03252

PROTEIN NAME

LMNB2

SYNONYMS

LAMB 2 antibody;LAMB2 antibody;Lamin-B2 antibody;Lamin B2 antibody;LMN 2 antibody;LMN B2 antibody;LMN2 antibody;LMNB 2 antibody;LMNB2 antibody;LMNB2_HUMAN antibody;MGC2721 antibody;RGD1563803 antibody

SEQUENCE SIMILARITIES

Belongs to the intermediate filament family.

POST-TRANSLATIONAL MODIFICATION

B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.

SUBCELLULAR LOCATION

Nucleus lamina.

FUNCTION

Lamin B2 is a protein that in humans is encoded by the LMNB2 gene. It is the second of two type B nuclear lamins, and it is associated with laminopathies. Model organisms have been used in the study of Lamin B2 function. A conditional knockout mouse line, called Lmnb2tm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on mutant mice and four significant abnormalities were observed. No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice. Male heterozygotes displayed increased circulating creatinine levels and an increased susceptibility to Salmonella infection.