LMNB2 Rabbit Polyclonal Antibody (ER0403)

UNIPROT #

Q03252

PROTEIN NAME

LMNB2

SYNONYMS

LAMB 2 antibody;LAMB2 antibody;Lamin-B2 antibody;LMN 2 antibody;LMN B2 antibody;LMN2 antibody;LMNB 2 antibody;LMNB2 antibody;LMNB2_HUMAN antibody;MGC2721 antibody;RGD1563803 antibody

SEQUENCE SIMILARITIES

Belongs to the intermediate filament family.

POST-TRANSLATIONAL MODIFICATION

B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.

SUBCELLULAR LOCATION

Nucleus inner membrane

FUNCTION

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations. Defects in LMNB2 are a cause of partial acquired lipodystrophy (APLD), which is a rare childhood disease characterized by loss of subcutaneous fat from the face and trunk.