LKB1 Recombinant Rabbit Monoclonal Antibody [PSH09-29] (HA723087)

UNIPROT #

Q15831

PROTEIN NAME

LKB1

SYNONYMS

hLKB1 antibody;Liver kinase B1 antibody;LKB1 antibody;PJS antibody;Polarization related protein LKB1 antibody;Renal carcinoma antigen NY-REN-19 antibody;Serine/Threonine Kinase 11 antibody;Serine/threonine protein kinase 11 antibody;Serine/threonine protein kinase LKB1 antibody;Serine/threonine protein kinase STK11 antibody;Serine/threonine-protein kinase 11 antibody;Serine/threonine-protein kinase LKB1 antibody;Serine/threonine-protein kinase XEEK1 antibody;Stk11 antibody;STK11_HUMAN antibody

SUBCELLULAR LOCATION

Nucleus, Cytoplasm, Membrane, Mitochondrion.

FUNCTION

The STK11/LKB1 gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumour suppressor. LKB1 is a primary upstream kinase of adenosine monophosphate-activated protein kinase (AMPK), a necessary element in cell metabolism that is required for maintaining energy homeostasis. It is now clear that LKB1 exerts its growth suppressing effects by activating a group of ~14 other kinases, comprising AMPK and AMPK-related kinases. Activation of AMPK by LKB1 suppresses growth and proliferation when energy and nutrient levels are scarce. Activation of AMPK-related kinases by LKB1 plays vital roles maintaining cell polarity thereby inhibiting inappropriate expansion of tumour cells. A picture from current research is emerging that loss of LKB1 leads to disorganization of cell polarity and facilitates tumour growth under energetically unfavorable conditions. A study in rats showed that LKB1 expression is upregulated in cardiomyocytes after birth and that LKB1 abundance negatively correlates with proliferation of neonatal rat cardiomyocytes.