PRODUCT CODE: ET7107-90

Liver Arginase Recombinant Rabbit Monoclonal Antibody [JB21-49] (ET7107-90)

  • Recombinant

Applications

  • WB

  • IHC-P

  • IP

REACTIVITY

  • Human

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Western blot analysis of Liver Arginase on human liver tissue lysate using anti-Liver Arginase antibody at 1/500 dilution.
  • Western blot analysis of Liver Arginase on human liver tissue lysate using anti-Liver Arginase antibody at 1/500 dilution.
  • Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-Liver Arginase antibody. Counter stained with hematoxylin.
Western blot analysis of Liver Arginase on human liver tissue lysate using anti-Liver Arginase antibody at 1/500 dilution.

Applications

  • WB

  • IHC-P

  • IP

REACTIVITY

  • Human

SPECIFICATIONS

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Liver Arginase Recombinant Rabbit Monoclonal Antibody [JB21-49] (ET7107-90)

Immunogen

Recombinant protein

Host

Rabbit

Positive Control

Human liver tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JB21-49

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Protein A purified.

MOLECULAR WEIGHT

36 kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:500-1:2,000

  • IHC-P

  • 1:50-1:200

  • IP

  • 1:10-1:50

TARGET

UNIPROT #

PROTEIN NAME

Liver Arginase

SYNONYMS

A I antibody; Al antibody; ARG 1 antibody; arg1 antibody; ARGI1_HUMAN antibody; Arginase 1 antibody; Arginase liver antibody; Arginase type I antibody; Arginase, liver antibody; Arginase-1 antibody; Arginase1 antibody; Liver type arginase antibody; Liver-type arginase antibody; Type I arginase antibody

SEQUENCE SIMILARITIES

Belongs to the arginase family.

TISSUE SPECIFICITY

Within the immune system initially reported to be selectively expressed in granulocytes (polymorphonuclear leukocytes [PMNs]). Also detected in macrophages mycobacterial granulomas. Expressed in group2 innate lymphoid cells (ILC2s) during lung disease.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Arginase I (also designated liver-type arginase), which is expressed almost exclusively in the liver, catalyzes the conversion of arginine to ornithine and urea. Arginase I exists as a homotrimeric protein and contains a binuclear manganese cluster. Arginase II catalyzes the same reaction as arginase I, but differs in its tissue specificity and subcellular location. Specifically, arginase II localizes to the mitochondria. Arginase II is expressed in non-hepatic tissues, with the highest levels of expression in the kidneys, but, unlike arginase I, is not expressed in liver. In addition, arginase II contains a putative amino-terminal mitochondrial localization sequence..