UNIPROT #

P05089

PROTEIN NAME

Liver Arginase

SYNONYMS

A I antibody; Al antibody; ARG 1 antibody; arg1 antibody; ARGI1_HUMAN antibody; Arginase 1 antibody; Arginase liver antibody; Arginase type I antibody; Arginase, liver antibody; Arginase-1 antibody; Arginase1 antibody; Liver type arginase antibody; Liver-type arginase antibody; Type I arginase antibody

SEQUENCE SIMILARITIES

Belongs to the arginase family.

TISSUE SPECIFICITY

Within the immune system initially reported to be selectively expressed in granulocytes (polymorphonuclear leukocytes [PMNs]). Also detected in macrophages mycobacterial granulomas. Expressed in group2 innate lymphoid cells (ILC2s) during lung disease.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Arginase I (also designated liver-type arginase), which is expressed almost exclusively in the liver, catalyzes the conversion of arginine to ornithine and urea. Arginase I exists as a homotrimeric protein and contains a binuclear manganese cluster. Arginase II catalyzes the same reaction as arginase I, but differs in its tissue specificity and subcellular location. Specifically, arginase II localizes to the mitochondria. Arginase II is expressed in non-hepatic tissues, with the highest levels of expression in the kidneys, but, unlike arginase I, is not expressed in liver. In addition, arginase II contains a putative amino-terminal mitochondrial localization sequence..