Lipoprotein lipase Recombinant Rabbit Monoclonal Antibody [JA22-02] (ET1704-48)
Catalog# ET1704-48
Rabbit Monoclonal to Lipoprotein lipase
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WB
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IHC-P
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Human
Specifications
Product Type
Recombinant Rabbit monoclonal primary
Product Name
Lipoprotein lipase Recombinant Rabbit Monoclonal Antibody [JA22-02] (ET1704-48)
Immunogen
Synthetic peptide within human lipoprotein lipase aa 456-475 / 475.
Host
Rabbit
Positive Control
Human placenta tissue lysates, human ileum tissue, human pancreas tissue.
Conjugation
Unconjugated
Clonality
Monoclonal
Clone Number
JA22-02
RRID
APPLICATION DILUTION
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WB
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1:500-1:1,000
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IHC-P
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1:50-1:200
PROPERTIES
Form
Liquid
Storage Condition
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Protein A affinity purified.
Molecular Weight
Predicted band size: 53 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
Lipoprotein lipase
SYNONYMS
EC 3.1.1 antibody;EC 3.1.1.34 antibody;HDLCQ11 antibody;LIPD antibody;LIPL_HUMAN antibody;Lipoprotein lipase antibody;LPL antibody;LPL protein antibody;MGC137861 antibody
SEQUENCE SIMILARITIES
Belongs to the AB hydrolase superfamily. Lipase family.
TISSUE SPECIFICITY
Detected in blood plasma. Detected in milk (at protein level).
POST-TRANSLATIONAL MODIFICATION
Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
SUBCELLULAR LOCATION
Cell membrane. Secreted.
FUNCTION
The Lipase gene family belongs to one of the most robust genetic superfamilies found in living organisms, which includes esterases and thioesterases. Lipase gene products are related by tertiary structure rather than primary amino acid sequence. Members of the AB hydrolase subfamily include hepatic lipase (HL), endothelial lipase (EL), lipoprotein lipase (LPL) and pancreatic lipase (PL). HL balances the composition and transport of lipoproteins in human plasma. Synthesized in endothelial cells, EL hydrolyzes high density lipoproteins. LPL, a homodimer attached to the membrane by a GPI-anchor, mediates the hydrolysis of triglycerides of very low density lipoproteins and circulating chylomicrons. Defects in LPL may cause chylomicronemia syndrome or a form of lipoprotein lipase deficiency characterized by hypertriglyceridemia.
CITATIONS
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YY1/miR-140-5p/Jagged1/Notch axis mediates cartilage progenitor/stem cells fate reprogramming in knee osteoarthritis
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WB
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Human
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Citation
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