Legumain Recombinant Rabbit Monoclonal Antibody [JE35-56] (HA721645)

UNIPROT #

Q99538

PROTEIN NAME

Legumain

SYNONYMS

AEP antibody;Asparaginyl endopeptidase antibody;cysteine 1 antibody;Cysteine protease 1 antibody;EC 3.4.22.34 antibody;Legumain antibody;LGMN antibody;LGMN_HUMAN antibody;LGMN1 antibody;Protease antibody;Protease cysteine 1 (legumain) antibody;Protease cysteine 1 antibody;PRSC1 antibody

SUBCELLULAR LOCATION

Lysosome.

FUNCTION

Legumain is a protein that in humans is encoded by the LGMN gene. This gene encodes a cysteine protease, legumain, that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.