Recombinant Rabbit monoclonal primary
LDL Receptor Recombinant Rabbit Monoclonal Antibody [SJ0197] (ET1606-47)
A549, MCF-7, Hela, HepG2, human liver tissue, human liver cancer tissue, human lung tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
FH antibody; FHC antibody; LDL R antibody; LDL receptor antibody; LDLCQ2 antibody; Ldlr antibody; LDLR_HUMAN antibody; Low Density Lipoprotein Receptor antibody; Low density lipoprotein receptor class A domain containing protein 3 antibody; Low density lipoprotein receptor familial hypercholesterolemia antibody; Low-density lipoprotein receptor antibody
Belongs to the LDLR family.
N- and O-glycosylated.; Ubiquitinated by MYLIP leading to degradation.
Membrane, Cell surface, Endosome.
LDLR (low density lipoprotein receptor) is a member of the LDL receptor gene family, which includes LDLR, LRP, Megalin, VLDLR, and ApoER2. The LDL receptor family is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats, and an O-linked sugar domain. The LDL receptor is a cell surface transmembrane protein that mediates the uptake of low density lipoprotein and its degradation in the lysosome, which provides cholesterol to cells. The cytoplasmic domain of the LDL receptor is necessary for the receptor to cluster in coated pits, which promotes the rapid endocytosis of bound LDL. Mutations in LDLR cause the autosomal dominant disease, familial hypercholesterolemia (FH), which promotes premature coronary atherosclerosis.