Lck Rabbit Polyclonal Antibody (HA500280)

UNIPROT #

P06239

PROTEIN NAME

Lck

SYNONYMS

IMD22 antibody;LCK antibody;Lck p56 antibody;LCK proto-oncogene, Src family tyrosine kinase antibody;LCK_HUMAN antibody;Leukocyte C-terminal Src kinase antibody;LSK antibody;Lymphocyte cell specific protein tyrosine kinase antibody;Lymphocyte cell-specific protein-tyrosine kinase antibody;Lymphocyte specific protein tyrosine kinase antibody;Membrane associated protein tyrosine kinase antibody;Oncogene lck antibody;P56 LCK antibody;p56(LSTRA) protein tyrosine kinase antibody;p56-LCK antibody;p56lck antibody;pp58 lck antibody;pp58lck antibody;Protein YT16 antibody;Proto oncogene tyrosine protein kinase LCK antibody;Proto-oncogene Lck antibody;Protooncogene tyrosine protein kinase LCK antibody;T cell specific protein tyrosine kinase antibody;T cell-specific protein-tyrosine kinase antibody;T lymphocyte specific protein tyrosine kinase p56lck antibody;Tyrosine-protein kinase Lck antibody;YT 16 antibody;YT16 antibody

SUBCELLULAR LOCATION

Cytosol, Cell membrane.

FUNCTION

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described.