LARP1 Recombinant Rabbit Monoclonal Antibody [PSH12-09] (HA723425)

UNIPROT #

Q6PKG0

PROTEIN NAME

LARP1

SYNONYMS

1810024J12Rik antibody;3110040D16Rik antibody;KIAA0731 antibody;La related protein antibody;La ribonucleoprotein domain family, member 1 antibody;LARP antibody;MGC19556 antibody;mKIAA0731 antibody;rCG_32791 antibody;RGD1306683 antibody;RP23-293I3.7 antibody

SUBCELLULAR LOCATION

Cytoplasm, Cytoplasmic granule.

FUNCTION

La-related protein 1 (LARP1) is a 150 kDa protein that in humans is encoded by the LARP1 gene. LARP1 is a novel target of the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, a circuitry often hyperactivated in cancer which regulates cell growth and proliferation primarily through the regulation of protein synthesis. LARP1 is the largest of a 7-member family of LARP proteins (others are: LARP1B, LARP3 (aka genuine La or SSB), LARP4A, LARP4B, LARP6 and LARP7). All LARP proteins, including human LARPs, contain 2 conserved regions. The first conserved region shares homology with La proteins (called the La motif, see SSB) whereas the second conserved region (called the LA- motif) is restricted to LARP proteins. LARP1 and 1B also contain a conserved "DM15 region" within their C-terminus. This region is unique and has been shown to be required for RNA-binding. Mouse Larp1 is expressed in dorsal root ganglia and spinal cord, as well as in developing organs characterized by epithelial-mesenchymal interactions. Human LARP1 is present at low levels in normal, non-embryonic cells but is highly expressed in epithelial cancers (such as ovarian, colorectal, prostate, non-small cell lung, hepatocellular and cervical cancers). Some studies have shown that high levels of LARP1 protein correlate with worse prognosis in cancer patients.