Lane 1: human liver tissue lysate
Lane 2: JAR cell lysate
Lane 3: human placenta tissue lysate
Lane 4: human lung tissue lysate
Recombinant Rabbit monoclonal primary
LAMP2a Recombinant Rabbit Monoclonal Antibody [SA46-01] (ET1601-24)
Synthetic peptide within c-terminal human lamp2a.
Human liver tissue lysate, JAR cell lysate, human placenta tissue lysate, human lung tissue lysate, human liver tissue, human kidney tissue, human pancreas tissue, mouse kidney tissue, mouse placenta tissue, mouse pancreas tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
CD107 antigen-like family member B antibody; CD107b antibody; LAMP 2 antibody; Lamp 2a antibody; LAMP-2 antibody; LAMP2 antibody; LAMP2_HUMAN antibody; Lysosome-associated membrane glycoprotein 2 antibody; Lysosome-associated membrane protein 2 antibody
Belongs to the LAMP family.
Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle. Isoform LAMP-2B is detected in spleen, thymus, prostate, testis, small intestine, colon, skeletal muscle, brain, placenta, lung, kidney, ovary and pancreas and liver. Isoform LAMP-2C is detected in small intestine, colon, heart, brain, skeletal muscle, and at lower levels in kidney and placenta.
O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.
Cell membrane, Endosome membrane, Lysosome membrane
Lysosome-associated membrane proteins (LAMP) are glycosylated type I membrane proteins that play a role in the biogenesis of the pigment melanin. LAMP-1 (also designated CD107A) and LAMP-2 (also designated CD107B) are involved in a variety of functions, including cellular adhesion, and are thought to participate in the process of tumor invasion and metastasis. Newly synthesized LAMP-1 and LAMP-2 proteins are sorted at the trans Golgi network and are transported intracellularly via a pathway that is distinct from the clathrin-coated vesicles used for the mannose-6 phosphate receptor. LAMP-1 is expressed on the surface of thrombin-activated but not resting platelets, and it is thought to be involved in the adhesive, prothrombic properties of these cells. Both LAMP-1 and LAMP-2 are involved in maintaining lysosome acidity and protecting the lysosomal membranes from autodigestion, and their expression is increased in patients with lysosomal storage disorders.
Wang, Ruibo et al.
Tumor cells induce LAMP2a expression in tumor-associated macrophage for cancer progression. | EbioMedicine