Lamin B1 Rabbit Polyclonal Antibody (R1508-1)

UNIPROT #

P20700

PROTEIN NAME

Lamin B1

SYNONYMS

ADLD antibody;lamin B1 antibody;Lamin-B1 antibody;LMN antibody;LMN2 antibody;LMNB antibody;Lmnb1 antibody;LMNB1_HUMAN antibody;MGC111419 antibody;OTTHUMP00000159218 antibody

SEQUENCE SIMILARITIES

Belongs to the intermediate filament family.

POST-TRANSLATIONAL MODIFICATION

B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.

SUBCELLULAR LOCATION

Intermediate filament, Nucleus.

FUNCTION

Lamin-B1 is a protein that in humans is encoded by the LMNB1 gene. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Lamin B, along with heterochromatin, is anchored to the inner surface of the nuclear membrane by the lamin B receptor. LMNB1 has been shown to interact with Thymopoietin.