Positive control:
Lane 1: MCF-7
Lane 2: Mouse marrow
Applications
-
WB
-
ICC
-
IHC-P
-
FC
REACTIVITY
-
Human
-
Mouse
SPECIFICATIONS
Product Type
Rabbit polyclonal primary
Product Name
KV4.3 Rabbit Polyclonal Antibody (ER1802-91)
Immunogen
Synthetic peptide within human kv43 aa 435-484 / 655.
Host
Rabbit
Positive Control
MCF-7, mouse marrow tissue, LOVO, MG-63, human esophagus tissue, human placenta tissue, mouse cerebellum tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Peptide affinity purified.
MOLECULAR WEIGHT
73 kDa
Isotype
IgG
APPLICATION DILUTION
-
WB
-
1:500-1:1,000
-
ICC
-
1:200
-
IHC-P
-
1:50-1:200
-
FC
-
1:50-1:100
TARGET
UNIPROT #
PROTEIN NAME
KV4.3
SYNONYMS
KCND 3 antibody; KCND 3L antibody; KCND 3S antibody; Kcnd3 antibody; KCND3_HUMAN antibody; KCND3L antibody; KCND3S antibody; KSHIVB antibody; Kv 4.3 antibody; MGC14203 antibody; MGC142037 antibody; OTTHUMP00000063948 antibody; Potassium ioinic channel Kv4.3 antibody; Potassium voltage gated channel Shal related subfamily member 3 antibody; Potassium voltage gated channel subfamily D member 3 antibody; Potassium voltage-gated channel subfamily D member 3 antibody; Sha1 related potassium channel Kv4.3 antibody; Voltage gated K+ channel antibody; Voltage gated potassium channel Kv4.3 antibody; Voltage gated potassium channel subunit Kv4.3 antibody; Voltage-gated potassium channel subunit Kv4.3 antibody
SEQUENCE SIMILARITIES
Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily.
TISSUE SPECIFICITY
Highly expressed in heart and brain, in particular in cortex, cerebellum, amygdala and caudate nucleus. Detected at lower levels in liver, skeletal muscle, kidney and pancreas. Isoform 1 predominates in most tissues. Isoform 1 and isoform 2 are detected at similar levels in brain, skeletal muscle and pancreas.
POST-TRANSLATIONAL MODIFICATION
Regulated through phosphorylation at Ser-569 by CaMK2D.
SUBCELLULAR LOCATION
Cell membrane.
FUNCTION
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.