Kv4.2 / KCND2 Recombinant Mouse Monoclonal Antibody [PSH13-21] (HA601434)

UNIPROT #

Q9Z0V2

PROTEIN NAME

Kv4.2 / KCND2

SYNONYMS

KCD2 antibody;KCND 2 antibody;KCND2 antibody;KCND2_HUMAN antibody;KIAA1044 antibody;MGC119702 antibody;MGC119703 antibody;Potassium voltage gated channel Shal related subfamily member 2 antibody;Potassium voltage-gated channel subfamily D member 2 antibody;RK 5 antibody;RK5 antibody;Voltage gated potassium channel Kv4.2 antibody;Voltage gated potassium channel subunit Kv4.2 antibody;Voltage sensitive potassium channel antibody;Voltage-gated potassium channel subunit Kv4.2 antibody

SUBCELLULAR LOCATION

Cell membrane, Cell projection, dendrite, Synapse, Perikaryon, Postsynaptic cell membrane, Cell projection, Cell junction.

FUNCTION

Potassium voltage-gated channel subfamily D member 2 is a protein that in humans is encoded by the KCND2 gene. It contributes to the cardiac transient outward potassium current (Ito1), the main contributing current to the repolarizing phase 1 of the cardiac action potential. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels.