Ku70 Mouse Monoclonal Antibody [D1-A6] (EM50109)

UNIPROT #

P12956

PROTEIN NAME

Ku70

SYNONYMS

5'-deoxyribose-5-phosphate lyase Ku70 antibody;5'-dRP lyase Ku70 antibody;70 kDa subunit of Ku antigen antibody;ATP dependent DNA helicase 2 subunit 1 antibody;ATP dependent DNA helicase II 70 kDa subunit antibody;ATP-dependent DNA helicase 2 subunit 1 antibody;ATP-dependent DNA helicase II 70 kDa subunit antibody;CTC box binding factor 75 kDa subunit antibody;CTC box-binding factor 75 kDa subunit antibody;CTC75 antibody;CTCBF antibody;DNA repair protein XRCC6 antibody;G22P1 antibody;Ku 70 antibody;Ku autoantigen p70 subunit antibody;Ku autoantigen, 70kDa antibody;Ku p70 antibody;Ku70 antibody;Ku70 DNA binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa antibody;Kup70 antibody;Lupus Ku autoantigen protein p70 antibody;ML8 antibody;Thyroid autoantigen 70kD (Ku antigen) antibody;Thyroid autoantigen antibody;Thyroid lupus autoantigen antibody;Thyroid lupus autoantigen p70 antibody;Thyroid-lupus autoantigen antibody;TLAA antibody;X ray repair complementing defective repair in Chinese hamster cells 6 antibody;X-ray repair complementing defective repair in Chinese hamster cells 6 antibody;X-ray repair cross-complementing protein 6 antibody;XRCC 6 antibody;Xrcc6 antibody;XRCC6_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the ku70 family.

DEVELOPMENTAL STAGE

Expression does not increase during promyelocyte differentiation.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation by PRKDC may enhance helicase activity. Phosphorylation of Ser-51 does not affect DNA repair.; ADP-ribosylated by PARP3.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. It is also required for V(D)J recombination, which utilizes the NHEJ pathway to promote antigen diversity in the mammalian immune system.In addition to its role in NHEJ, Ku is also required for telomere length maintenance and subtelomeric gene silencing. Ku was originally identified when patients with systemic lupus erythematosus were found to have high levels of autoantibodies to the protein.