Ku70 Recombinant Rabbit Monoclonal Antibody [JM61-31] (ET1703-95)

UNIPROT #

P12956

PROTEIN NAME

Ku 70

SYNONYMS

5'-deoxyribose-5-phosphate lyase Ku70 antibody;5'-dRP lyase Ku70 antibody;70 kDa subunit of Ku antigen antibody;ATP dependent DNA helicase 2 subunit 1 antibody;ATP dependent DNA helicase II 70 kDa subunit antibody;ATP-dependent DNA helicase 2 subunit 1 antibody;ATP-dependent DNA helicase II 70 kDa subunit antibody;CTC box binding factor 75 kDa subunit antibody;CTC box-binding factor 75 kDa subunit antibody;CTC75 antibody;CTCBF antibody;DNA repair protein XRCC6 antibody;G22P1 antibody;Ku 70 antibody;Ku autoantigen p70 subunit antibody;Ku autoantigen, 70kDa antibody;Ku p70 antibody;Ku70 antibody;Ku70 DNA binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa antibody;Kup70 antibody;Lupus Ku autoantigen protein p70 antibody;ML8 antibody;Thyroid autoantigen 70kD (Ku antigen) antibody;Thyroid autoantigen antibody;Thyroid lupus autoantigen antibody;Thyroid lupus autoantigen p70 antibody;Thyroid-lupus autoantigen antibody;TLAA antibody;X ray repair complementing defective repair in Chinese hamster cells 6 antibody;X-ray repair complementing defective repair in Chinese hamster cells 6 antibody;X-ray repair cross-complementing protein 6 antibody;XRCC 6 antibody;Xrcc6 antibody;XRCC6_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the ku70 family.

DEVELOPMENTAL STAGE

Expression does not increase during promyelocyte differentiation.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation by PRKDC may enhance helicase activity. Phosphorylation of Ser-51 does not affect DNA repair.; ADP-ribosylated by PARP3.

SUBCELLULAR LOCATION

Nucleus. Chromosome.

FUNCTION

The Ku protein is localized in the nucleus and is composed of subunits referred to as Ku-70 (p70) and Ku-86 (p86) which is also known by the synonym Ku-80 or (p80). Ku was first described as an autoantigen to which antibodies were produced in a patient with scleroderma polymyositis overlap syndrome, and was later found in the sera of patients with other rheumatic diseases. Both subunits of the Ku protein have been cloned, and a number of functions have been proposed for Ku, including cell signaling, DNA replication and transcriptional activation. Ku is involved in Pol II-directed transcription by virtue of its DNA binding activity, serving as the regulatory component of the DNA-associated protein kinase that phosphorylates Pol II and transcription factor Sp. Ku proteins also activate transcription from the U1 small nuclear RNA and the human transferrin receptor gene promoters. A Ku-related protein designated the enhancer 1 binding factor (E1BF), composed of two subunits, has been identified as a positive regulator of RNA polymerase I transcription initiation.