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KPTN Rabbit Polyclonal Antibody (ER2001-17)

Price: Regular price $315.00

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Catalog# ER2001-17

Rabbit Polyclonal to KPTN

Tested for

  • WB

  • IHC-P

  • IF-Cell

  • FC

Reacts with

  • Human

  • Mouse

  • Rat

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Specifications

Product Type

Rabbit polyclonal primary

Product Name

KPTN Rabbit Polyclonal Antibody (ER2001-17)

Immunogen

Synthetic peptide within n-terminal human kptn.

Host

Rabbit

Positive Control

HepG2 cell lysate, SH-SY5Y cell lysate, rat brain tissue lysate, human placenta tissue, mouse testis tissue, SH-SY5Y.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3069496

APPLICATION DILUTION

  • WB

  • 1:500-1:2,000

  • IHC-P

  • 1:50-1:200

  • IF-Cell

  • 1:250

  • FC

  • 1:1,000

PROPERTIES

Form

Liquid

Storage Condition

Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.

Storage Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

Predicted band size: 48 kDa

Isotype

IgG

TARGET

UNIPROT #

Q96GT1

PROTEIN NAME

KPTN

SYNONYMS

2E4 antibody;actin associated protein 2E4 antibody;actin binding protein antibody;Actin-associated protein 2E4 antibody;Kaptin antibody;Kptn antibody;KPTN protein antibody;KPTN_HUMAN antibody

SUBCELLULAR LOCATION

Lysosome membrane, lamellipodium, stereocilium.

FUNCTION

As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. Mutations in this gene result in an autosomal recessive form of intellectual disability. Alternatively spliced transcript variants have been found for this gene.

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