KLHL15 Rabbit Polyclonal Antibody (R1407-2)

UNIPROT #

Q96M94

PROTEIN NAME

KLHL15

SYNONYMS

Kelch like 15 (Drosophila) antibody;Kelch like 15 antibody;Kelch-like protein 15 antibody;KIAA1677 antibody;KLH15_HUMAN antibody;KLHL15 antibody;MGC126148 antibody;MGC126149 antibody;OTTHUMP00000023075 antibody

SUBCELLULAR LOCATION

Cytoplasm

FUNCTION

Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex. Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR). This gene encodes a member of the kelch-like family of proteins that share a common domain structure consisting of an N-terminal broad-complex, tramtrack, bric-a-brac/poxvirus and zinc finger domain and C-terminal kelch repeat motifs. The encoded protein may be involved in protein ubiquitination and cytoskeletal organization.