UNIPROT #

Q92945

PROTEIN NAME

KHSRP

SYNONYMS

Far upstream element-binding protein 2 antibody; FBP2 antibody; FUBP2 antibody; FUBP2_HUMAN antibody; FUSE binding protein 2 antibody; FUSE-binding protein 2 antibody; KH type splicing regulatory protein (FUSE binding protein 2) antibody; KH type splicing regulatory protein antibody; KH type-splicing regulatory protein antibody; KHSRP antibody; KSRP antibody; p75 antibody

SEQUENCE SIMILARITIES

Belongs to the KHSRP family.

TISSUE SPECIFICITY

Detected in neural and non-neural cell lines.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation at Ser-193 leads to the unfolding of the unstable KH domain 1, creating a site for 14-3-3 YWHAZ binding, which promotes nuclear localization and impairs the RNA degradation function.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.