Rabbit polyclonal primary
KCNQ4 Rabbit Polyclonal Antibody (ER2001-23)
Synthetic peptide within mouse kcnq4 aa 580-640.
Rat kidney tissue lysates, 293T, rat smooth muscle tissue, mouse brain tissue, K562.
Store at +4Á¾ after thawing. Aliquot store at -20Á¾. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified.
DFNA 2 antibody; DFNA2 antibody; KCNQ 4 antibody; Kcnq4 antibody; KCNQ4_HUMAN antibody; KQT like 4 antibody; KQT-like 4 antibody; KV7.4 antibody; Potassium channel KQT like 4 antibody; Potassium channel subunit alpha KvLQT4 antibody; Potassium voltage gated channel KQT like protein 4 antibody; Potassium voltage gated channel KQT like subfamily member 4 antibody; Potassium voltage gated channel subfamily KQT member 4 antibody; Potassium voltage-gated channel subfamily KQT member 4 antibody; Voltage gated potassium channel subunit Kv7.4 antibody; Voltage-gated potassium channel subunit Kv7.4 antibody
Cell membrane, Membrane.
Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors. Mutagenesis experiments were carried out by expressing in Xenopus oocytes KCNQ4 mutants either individually (homomultimers) or in combination with wild-type KCNQ4 (mut/wt homomultimers) in a ratio of 1:1, to mimic the situation in a heterozygous DFNA2 patient.