KCNN2 Rabbit Polyclonal Antibody (ER1902-41)

UNIPROT #

Q9H2S1

PROTEIN NAME

KCNN2

SYNONYMS

Apamin sensitive small conductance Ca2+ activated potassium antibody;Apamin sensitive small conductance Ca2+ activated potassium channel antibody;hSK2 antibody;KCa2.2 antibody;Kcnn2 antibody;KCNN2_HUMAN antibody;Potassium intermediate/small conductance calcium activated antibody;Potassium intermediate/small conductance calcium activated channel subfamily N member 2 antibody;SK2 antibody;SKCa 2 antibody;SKCa2 antibody;Small conductance calcium activated potassium channel antibody;Small conductance calcium activated potassium channel protein 2 antibody;Small conductance calcium-activated potassium channel protein 2 antibody

SEQUENCE SIMILARITIES

Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily.

TISSUE SPECIFICITY

Expressed in atrial myocytes (at protein level). Widely expressed.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2, also known as KCNN2, is a protein which in humans is encoded by the KCNN2 gene. KCNN2 is an ion channel protein also known as KCa2.2. Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The KCa2.2 protein is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. KCa2.2 is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This protein is a member of the calcium-activated potassium channel family. Two transcript variants encoding different isoforms have been found for the KCNN2 gene.